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apalutamide will minimize the extent or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medication which can be CYP2C19 substrates may lead to lower exposure to those medicines.tazemetostat will lessen the level or outcome of diazepam by i